Nep1-like proteins as a target for plant pathogen control

Phytotoxicity and innate immune responses induced by Nep1-like proteins.

We show that oomycete-derived Nep1 (for necrosis and ethylene-inducing peptide1)-like proteins (NLPs) trigger a comprehensive immune response in Arabidopsis thaliana, comprising posttranslational activation of mitogen-activated protein kinase activity, deposition of callose, production of nitric oxide, reactive oxygen intermediates, ethylene, and the phytoalexin camalexin, as well as cell death...

Plant pathogen effector proteins as manipulators of host microbiomes?

To understand the mechanisms underlying disease development in plants, molecular plant pathology research has mostly focused on the characterization of direct interactions between plant pathogens and their hosts. Collectively, this research has demonstrated that plants sense microbial invaders using various types of receptors (recently coined as ‘invasion pattern receptors’, IPRs) that sense mi...

Polymorphisms of Antioxidant’ Genes as a Target for Diabetes Management

Diabetes mellitus (DM) is one of the most important health problems with increasing prevalence worldwide. Oxidative stress that is a result of imbalance between reactive oxygen species (ROS) generation and antioxidant defense mechanisms has been demonstrated as a main pathology in DM. Hyperglycemia-induced ROS productions can induce oxidative stress through four major molecular mechanisms inclu...

P14: Mitochondria as a Target for Drug Therapy in Epilepsy

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Camphor as a promising insecticude for control